Sildenafil attenuates TNBS-induced colitis in rats: possible involvement of cGMP and KATP channels

Sildenafil attenuates TNBS-induced colitis in rats: possible involvement of cGMP and KATP channels

The involvement of cGMP/KATP pathway in effects of sildenafil on experimental colitis was investigated. Sildenafil significantly attenuated colonic injury markers. These effects were reversed by the addition of glibenclamide or ODQ, indicating the involvement of ATP‐sensitive potassium channels (KAT...

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Veröffentlicht in:Fundamental & clinical pharmacology 2012-04, Vol.26 (2), p.190-193
Hauptverfasser: Fakhfouri, Gohar, Rahimian, Reza, Hashemi, Saeed, Rasouli, Mohammad Reza, Bahremand, Arash, Mehr, Shahram Ejtemaei, Khorramizadeh, Mohammad Reza, Dehpour, Ahmad Reza
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
cGMP
colitis
Colitis - drug therapy
Colitis - physiopathology
Cyclic GMP - metabolism
Disease Models, Animal
Glyburide - pharmacology
KATP
KATP Channels - metabolism
Male
Medical sciences
Pharmacology. Drug treatments
Phosphodiesterase 5 Inhibitors - pharmacology
Piperazines - pharmacology
Purines - pharmacology
Rats
Rats, Sprague-Dawley
sildenafil
Sildenafil Citrate
Sulfones - pharmacology
Trinitrobenzenesulfonic Acid - toxicity
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Zusammenfassung:The involvement of cGMP/KATP pathway in effects of sildenafil on experimental colitis was investigated. Sildenafil significantly attenuated colonic injury markers. These effects were reversed by the addition of glibenclamide or ODQ, indicating the involvement of ATP‐sensitive potassium channels (KATP) and cGMP, respectively.
ISSN:0767-3981
1472-8206
DOI:10.1111/j.1472-8206.2011.00928.x