Acute cadmium exposure causes systemic and thromboembolic events in mice

Cadmium (Cd), an environmental and industrial pollutant, poses a potential threat and affects many systems in human and animals. Although several reports on Cd toxicity were presented, the acute effect of Cd on systemic and thrombotic events was not reported so far. Cd (2.284 mg/kg) or saline (contr...

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Veröffentlicht in:	Physiological research 2012-01, Vol.61 (1), p.73-80
Hauptverfasser:	Fahim, M A, Nemmar, A, Dhanasekaran, S, Singh, S, Shafiullah, M, Yasin, J, Zia, S, Hasan, M Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Alanine Transaminase - metabolism Animals Apoptosis Brain Cadmium Cadmium - toxicity Creatinine - metabolism Endothelium Health sciences Inflammation - chemically induced Inflammation - metabolism Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Male Mice Mice, Inbred Strains Oxidative stress Oxidative Stress - drug effects Rodents Studies Thromboembolism - chemically induced Thromboembolism - metabolism
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Beschreibung
Zusammenfassung:	Cadmium (Cd), an environmental and industrial pollutant, poses a potential threat and affects many systems in human and animals. Although several reports on Cd toxicity were presented, the acute effect of Cd on systemic and thrombotic events was not reported so far. Cd (2.284 mg/kg) or saline (control) was injected intraperitoneally (ip), and the systemic parameters were assessed in mice. Compared to control group, acute intraperitoneal injection of Cd, in mice showed significant quickening of platelet aggregation (P
ISSN:	0862-8408 1802-9973
DOI:	10.33549/physiolres.932238