Ultrasound-assisted click chemistry in continuous flow

We present a study on ultrasound-promoted click chemistry reactions in a meso-flow reactor synthesis system with a copper reactor and a custom sonication piezoelectric transducer. Copper catalyzed Huisgen 1,3-dipolar cycloadditions were studied in flow with this system. Our results demonstrate that...

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Veröffentlicht in:	Molecular diversity 2012-02, Vol.16 (1), p.53-58
Hauptverfasser:	Tu, Noah P., Hochlowski, Jill E., Djuric, Stevan W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Area Under Curve Biochemistry Biomedical and Life Sciences Chemical reactions Chemical synthesis Chemistry Click Chemistry - methods Life Sciences Organic Chemistry Pharmacy Polymer Sciences Rheology Short Communication Temperature Transducers Triazoles - chemical synthesis Triazoles - chemistry Ultrasonic technology Ultrasonics - methods
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Beschreibung
Zusammenfassung:	We present a study on ultrasound-promoted click chemistry reactions in a meso-flow reactor synthesis system with a copper reactor and a custom sonication piezoelectric transducer. Copper catalyzed Huisgen 1,3-dipolar cycloadditions were studied in flow with this system. Our results demonstrate that 1,4-disubstituted 1,2,3-triazole products can be generated at low temperatures and with short reaction time in good yield, due to the rate enhancement effect of sonication.
ISSN:	1381-1991 1573-501X
DOI:	10.1007/s11030-011-9331-4