Extrathymically generated regulatory T cells control mucosal T^sub H^2 inflammation

Extrathymically generated regulatory T cells control mucosal T^sub H^2 inflammation

Two recent studies established a role for TGFb signalling in tTreg cell differentiation in neonates9,10. [...] to exclude the possibility that CNS1 deficiency adversely affects generation of Foxp31 T cells in the neonatal thymus, we examined the Foxp31 Treg cell population in heterozygous female CNS...

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Veröffentlicht in:Nature (London) 2012-02, Vol.482 (7385), p.395
Hauptverfasser: Josefowicz, Steven Z, Niec, Rachel E, Kim, Hye Young, Treuting, Piper, Chinen, Takatoshi, Zheng, Ye, Umetsu, Dale T, Rudensky, Alexander Y
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Asthma
Binding sites
Cell differentiation
Homeostasis
Lungs
Lymphocytes
Proteins
Rodents
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Zusammenfassung:Two recent studies established a role for TGFb signalling in tTreg cell differentiation in neonates9,10. [...] to exclude the possibility that CNS1 deficiency adversely affects generation of Foxp31 T cells in the neonatal thymus, we examined the Foxp31 Treg cell population in heterozygous female CNS1WT/2 mice.
ISSN:0028-0836
1476-4687