A Multiple Scale Model for Tumor Growth

A Multiple Scale Model for Tumor Growth

We present a physiologically structured lattice model for vascular tumor growth which accounts for blood flow and structural adaptation of the vasculature, transport of oxygen, interaction between cancerous and normal tissue, cell division, apoptosis, vascular endothelial growth factor release, and...

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Veröffentlicht in:Multiscale modeling & simulation 2005-01, Vol.3 (2), p.440-475
Hauptverfasser: Alarcón, T., Byrne, H. M., Maini, P. K.
Format: Artikel
Sprache:eng
Schlagworte:
Angiogenesis
Applied mathematics
Cancer
Cell division
Computer simulation
Hypoxia
Medical research
Metabolism
Scale models
Tumors
Vascular endothelial growth factor
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Zusammenfassung:We present a physiologically structured lattice model for vascular tumor growth which accounts for blood flow and structural adaptation of the vasculature, transport of oxygen, interaction between cancerous and normal tissue, cell division, apoptosis, vascular endothelial growth factor release, and the coupling between these processes. Simulations of the model are used to investigate the effects of nutrient heterogeneity, growth and invasion of cancerous tissue, and emergent growth laws.
ISSN:1540-3459
1540-3467
DOI:10.1137/040603760