EFFECT OF WHEAT BRAN ON POSTPRANDIAL GLUCOSE RESPONSE IN SUBJECTS WITH IMPAIRED FASTING GLUCOSE

In addition to long term effect of wheat bran on improvement of insulin sensitivity, its effect on the postprandial blood glucose response, in clinical implementation is important. Therefore the aim of this study was to measure the reduced postprandial blood glucose of impaired fasting blood glucose subjects following consuming high glycemic load (GL) meal containing 25 g wheat bran. Nine subjects were given each of the following 2 meals in a randomized order one week apart: a high-GL meal (control), and the same high GL meal plus wheat bran (test meal). Using glucometer, finger prick blood samples for glucose analysis were used before the meals (fasting) and at 30, 60, 90, and 120 min following the meal ingestion. At 90 and 120 min after the test meal ingestion, there was a 10.3% and 11% reduction in blood glucose concentration compared with control meal (P = 0.02, and 0.03 respectively). Also, there was positive correlation between 2 hrs postprandial blood glucose concentration of control and test meals (r = 0.95, P < 0.001 at 0.01 level). The repeated measures ANOVA, test of within-subjects effects, confirmed that the blood glucose profile over time differed between the 2 meal types (P < 0.03; n = 9, for the group by time interaction). [PUBLICATION ABSTRACT]