A Research-Based Undergraduate Organic Laboratory Project: Investigation of a One-Pot, Multicomponent, Environmentally Friendly Prins–Friedel–Crafts-Type Reaction

A Research-Based Undergraduate Organic Laboratory Project: Investigation of a One-Pot, Multicomponent, Environmentally Friendly Prins–Friedel–Crafts-Type Reaction

Students in the undergraduate organic laboratory synthesize tetrahydro-2-(4-nitrophenyl)-4-phenyl-2H-pyran via the Montmorillonite K10 clay-catalyzed reaction of p-nitrobenzaldehye with methanol, 3-buten-1-ol, and benzene. The synthesis comprises an environmentally friendly tandem Prins–Friedel–Craf...

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Veröffentlicht in:Journal of chemical education 2012-01, Vol.89 (2), p.265-267
Hauptverfasser: Dintzner, Matthew R, Maresh, Justin J, Kinzie, Charles R, Arena, Anthony F, Speltz, Thomas
Format: Artikel
Sprache:eng
Schlagworte:
Benzene
Carbonyl compounds
Carbonyls
Catalysis
Chemical compounds
Chemical reactions
Chemical synthesis
College Science
College students
Crafts
Laboratory Experiments
Montmorillonite
Organic Chemistry
Research projects
Science Activities
Science Experiments
Science Instruction
Student Projects
Student Research
Substrates
Undergraduate Students
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Beschreibung
Zusammenfassung:Students in the undergraduate organic laboratory synthesize tetrahydro-2-(4-nitrophenyl)-4-phenyl-2H-pyran via the Montmorillonite K10 clay-catalyzed reaction of p-nitrobenzaldehye with methanol, 3-buten-1-ol, and benzene. The synthesis comprises an environmentally friendly tandem Prins–Friedel–Crafts-type multicomponent reaction (MCR) and sets the stage for investigation of reaction scope through student research projects with other carbonyl substrates.
ISSN:0021-9584
1938-1328
DOI:10.1021/ed200256w