Glioblastoma multiforme with epithelial differentiation

Magnetic resonance imaging (MRI) brain showed multiple conglomerate well-defined peripherally enhancing cystic lesions in the right temporal pole extending medially. The neoplastic glial cells were strongly positive for gliofibrillary acidic protein (GFAP) [Figure 3]a whereas the epithelial cells showed only focal positivity (GFAP; 1:100) [Figure 3]b. The epithelial cells demonstrated strong cytoplasmic positivity for epithelial membrane antigen (EMA; 1:100) [Figure 3]c, and focal positivity for high molecular weight cytokeratin (HMWCK; 1:100 [Figure 3]d).