The role of memory-related gene polymorphisms, KIBRA and CLSTN2, on replicate memory assessment in the elderly

The role of memory-related gene polymorphisms, KIBRA and CLSTN2, on replicate memory assessment in the elderly

The role of the CLSTN2 (rs6439886) and KIBRA (rs17070145) SNPs in cognitive impairment was analysed in a 75–76 years old group. Various memory assessment tests were carried out on individuals at baseline and during follow-up investigations, and biallelic genotyping was performed. No influence of the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of Neural Transmission 2012, Vol.119 (1), p.77-80
Hauptverfasser: Sédille-Mostafaie, N., Sebesta, C., Huber, K. R., Zehetmayer, S., Jungwirth, S., Tragl, K. H., Fischer, P., Krugluger, W.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aging - genetics
Alzheimer Disease - diagnosis
Austria
Calcium-Binding Proteins - genetics
Cognitive Dysfunction - genetics
Dementias - Short communication
Female
Follow-Up Studies
Genotype
Humans
Intracellular Signaling Peptides and Proteins - genetics
Male
Medicine
Medicine & Public Health
Membrane Proteins - genetics
Memory
Neurology
Neuropsychological Tests
Neurosciences
Phosphoproteins - genetics
Polymorphism, Single Nucleotide - genetics
Psychiatry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The role of the CLSTN2 (rs6439886) and KIBRA (rs17070145) SNPs in cognitive impairment was analysed in a 75–76 years old group. Various memory assessment tests were carried out on individuals at baseline and during follow-up investigations, and biallelic genotyping was performed. No influence of the allele status of either SNPs was observed on any memory test. No increased risk of any type of late development, and cognitive impairment was associated with rs6439886 or rs17070145.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-011-0667-9