Activity of trabectidin in desmoplastic small round cell tumor

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive cancer that typically arises in teenage boys. As a result of its low prevalence, there have been few studies of its treatment and impact on survival. Here, we report the case of a patient who was refractory to multiple drugs but re...

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Veröffentlicht in:	Medical oncology (Northwood, London, England) London, England), 2011-12, Vol.28 (Suppl 1), p.644-646
Hauptverfasser:	López-González, Ana, Cantos, Blanca, Tejerina, Eva, Provencio, Mariano
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Desmoplastic Small Round Cell Tumor - diagnosis Desmoplastic Small Round Cell Tumor - drug therapy Desmoplastic Small Round Cell Tumor - metabolism Dioxoles - metabolism Dioxoles - therapeutic use Hematology Humans Internal Medicine Male Medicine Medicine & Public Health Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - metabolism Oncology Pathology Tetrahydroisoquinolines - metabolism Tetrahydroisoquinolines - therapeutic use
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Zusammenfassung:	Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive cancer that typically arises in teenage boys. As a result of its low prevalence, there have been few studies of its treatment and impact on survival. Here, we report the case of a patient who was refractory to multiple drugs but remains stable with trabectedin. To our knowledge, this is the first published report that supports antitumoral activity of trabectedin in DSRCT.
ISSN:	1357-0560 1559-131X
DOI:	10.1007/s12032-010-9687-9