In vitro suppression of drug‐induced methaemoglobin formation by Intralipid® in whole human blood: observations relevant to the ‘lipid sink theory’

Summary To provide further evidence for the lipid sink theory, we have developed an in vitro model to assess the effect of Intralipid® 20% on methaemoglobin formation by drugs of varying lipid solubility. Progressively increasing Intralipid concentrations from 4 to 24 mg.ml−1 suppressed methaemoglob...

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Veröffentlicht in:	Anaesthesia 2012-01, Vol.67 (1), p.23-32
Hauptverfasser:	Samuels, T. L., Willers, J. W., Uncles, D. R., Monteiro, R., Halloran, C., Dai, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood - drug effects Blood Gas Analysis Dose-Response Relationship, Drug Drug therapy Fat Emulsions, Intravenous - pharmacology Humans Lipids Lipids - blood Lipids - chemistry Medical sciences Methemoglobin - antagonists & inhibitors Methemoglobin - biosynthesis Models, Statistical Nitroglycerin - antagonists & inhibitors Nitroglycerin - chemistry Nitroglycerin - pharmacology Sodium Nitrite - antagonists & inhibitors Sodium Nitrite - chemistry Sodium Nitrite - pharmacology Solubility Vasodilator Agents - antagonists & inhibitors Vasodilator Agents - chemistry Vasodilator Agents - pharmacology
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Zusammenfassung:	Summary To provide further evidence for the lipid sink theory, we have developed an in vitro model to assess the effect of Intralipid® 20% on methaemoglobin formation by drugs of varying lipid solubility. Progressively increasing Intralipid concentrations from 4 to 24 mg.ml−1 suppressed methaemoglobin formation by the lipid soluble drug glyceryl trinitrate in a dose‐dependent manner (p
ISSN:	0003-2409 1365-2044
DOI:	10.1111/j.1365-2044.2011.06914.x