Controlled crystallisation during freeze-drying

Controlled crystallisation during freeze-drying

After 15 min on a precooled freeze-dryer shelf, only the TBA peak can be seen in the [Raman] spectrum (see Figure 2). This indicates that at this stage of the process, the solvents were still in the liquid state and that the solutes were still dissolved in these solvents. After 75 min, the intensity...

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Veröffentlicht in:Pharmaceutical technology Europe 2011-08, Vol.23 (8), p.14
Hauptverfasser: de Waard, Hans, Grasmeijer, Niels, Hinrichs, Wouter L J, De Beer, Thomas, Frijlink, Henderik W
Format: Artikel
Sprache:eng
Schlagworte:
Aqueous solutions
Clinical trials
Crystallization
Dissolution
Drugs
Freezing
Lasers
Nanocrystals
Nitrogen
Scanning electron microscopy
Software packages
Spectrum analysis
Studies
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Zusammenfassung:After 15 min on a precooled freeze-dryer shelf, only the TBA peak can be seen in the [Raman] spectrum (see Figure 2). This indicates that at this stage of the process, the solvents were still in the liquid state and that the solutes were still dissolved in these solvents. After 75 min, the intensity of the peak corresponding to ice increased, and the width of the TBA peak decreased.
ISSN:1753-7967