Investigation on Genetic Heterogeneity of [alpha]-Subunit of the Epithelial Sodium Channel in Rat Renal Cortex

Investigation on Genetic Heterogeneity of [alpha]-Subunit of the Epithelial Sodium Channel in Rat Renal Cortex

Genotypic variability of αENaC mRNA in adult rat kidney caused by deletion at the 3'-end of α-subunit DNA was studied by real-time PCR using specifi c probes with a fl uorescent dye (TaqMan). It was found that mRNA deletion forms (a and b), products of alternative splicing of aENaC gene, are ab...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2011-10, Vol.151 (6), p.709
Hauptverfasser: Logvinenko, N S, Herbeck, Y E, Ivanova, L N
Format: Artikel
Sprache:eng
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Zusammenfassung:Genotypic variability of αENaC mRNA in adult rat kidney caused by deletion at the 3'-end of α-subunit DNA was studied by real-time PCR using specifi c probes with a fl uorescent dye (TaqMan). It was found that mRNA deletion forms (a and b), products of alternative splicing of aENaC gene, are absent in the cortex of adult rat kidney.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1422-9