Influence of serum folic acid levels on plasma homocysteine concentrations in patients with rheumatoid arthritis

The purpose of this study was to investigate whether negative effects of methotrexate (mtx) on blood homocysteine (hmc) levels can be prevented with the replacement of folic acid. 42 female patients with rheumatoid arthritis (RA) were studied. Patients were separated into two groups according to the...

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Veröffentlicht in:	Rheumatology international 2006, Vol.26 (3), p.191-194
Hauptverfasser:	TIFTIKCI, Arzu, OZDEMIR, Ali, TARCIN, Ozlem, TARCIN, Orhan, INANC, Nevsun, SAHINOGLU, Sureyya, DIRESKENELI, Haner, YAVUZ, Sule, URAS, Fikriye, BARUT, Yildiz
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adolescent Adult Age Factors Aged Aged, 80 and over Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - drug therapy Biological and medical sciences Diseases of the osteoarticular system Female Folic Acid - blood Folic Acid - therapeutic use Homocysteine Homocysteine - blood Humans Hyperhomocysteinemia - drug therapy Hyperhomocysteinemia - etiology Immunosuppressive Agents - adverse effects Inflammatory joint diseases Medical sciences Methotrexate - adverse effects Middle Aged Rheumatoid arthritis Statistics, Nonparametric Vitamin B Vitamin B 12 - blood Vitamin B Complex - blood Vitamin B Complex - therapeutic use
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Zusammenfassung:	The purpose of this study was to investigate whether negative effects of methotrexate (mtx) on blood homocysteine (hmc) levels can be prevented with the replacement of folic acid. 42 female patients with rheumatoid arthritis (RA) were studied. Patients were separated into two groups according to their treatment status with mtx (group I: 27 patients taking mtx and folic acid; group II: 15 patients not using mtx). The level of hmc was found to be 6.3+/-2.4 micromol/l in group I and 7.87+/-3.2 micromol/l in group II (p>0.05). Folic acid levels of group I and II were found to be 21.3+/-15.9 ng/ml and 8.41+/-2.86 ng/ml respectively (p
ISSN:	0172-8172 1437-160X
DOI:	10.1007/s00296-004-0546-x