Metalloantitubercular compounds Part 3: Synthesis, crystal structure, spectroscopy, electrochemistry and antimycobacterial activity of the copper(II) ciproploxacin (cfH) complex and its phenanthroline adduct

The X-ray crystal structures of two ciprofloxacin compounds, viz. [Cu(cfH)^sub 2^(Cl)^sub 2^] · ^sub 2^MeOH · 6H^sub 2^O (2) and [Cu(cfH)(phen)Cl]BF^sub 4^ · 4H^sub 2^O (3) are reported. Complex (2) has a distorted octahedral geometry, whereas for the nitrogen adduct (3) a distorted square-pyramidal geometry is seen. Significant enhancement in the antimycobacterial activity of the copper conjugates correlates with their copper redox couples (Cu^sup 2+^ /Cu^sup +^) probably due to its relevance to intracellular accumulations and subsequent role in generating oxidative stress.[PUBLICATION ABSTRACT]