Effects of chondroitin sulfate and glucosamine in adult patients with Kaschin-Beck disease

The purpose is to investigate the effects of chondroitin sulfate and glucosamine on adult patients with Kaschin-Beck disease (KBD). A total of 80 patients, aged over 40 years, were randomized into two groups receiving either 1,600 mg oral mixture of chondroitin sulfate and glucosamine or placebo twi...

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Veröffentlicht in:	Clinical rheumatology 2010-04, Vol.29 (4), p.357-362
Hauptverfasser:	Zhang, Ya-xu, Dong, Wei, Liu, Hui, Cicuttini, Flavia, de Courten, Maximilian, Yang, Jian-bai
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Chondroitin Sulfates - therapeutic use Dietary Supplements Double-Blind Method Drug Combinations Female Glucosamine - therapeutic use Humans Male Medicine Medicine & Public Health Middle Aged Original Article Osteoarthritis - chemically induced Osteoarthritis - drug therapy Rheumatology T-2 Toxin - toxicity
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Zusammenfassung:	The purpose is to investigate the effects of chondroitin sulfate and glucosamine on adult patients with Kaschin-Beck disease (KBD). A total of 80 patients, aged over 40 years, were randomized into two groups receiving either 1,600 mg oral mixture of chondroitin sulfate and glucosamine or placebo twice daily for 8 months. Posteroanterior radiographs of bilateral knee in full extension were taken at enrollment and after 8 months. Mean joint-space width of the assigned six points on the tibiofemoral joint compartment was measured by a graduated magnifying lens. The mean joint space decreased significantly in the placebo group (4.3 ± 1.09 versus 4.1 ± 1.07 mm, P
ISSN:	0770-3198 1434-9949
DOI:	10.1007/s10067-009-1311-z