Antidiabetic activity of Nerium indicum leaf extract in alloxan-induced diabetic rats

This research aims to investigate the antidiabetic activity of Nerium indicum (Family: Apocynaceae) leaf extract in alloxan induced diabetic albino rats. A comparison was made between the action of Nerium indicum extracts and a known antidiabetic drug glibenclamide (600 µg/kg body wt.). An oral glucose tolerance test (OGTT) was also performed in experimental diabetic rats. The petroleum ether, chloroform, alcohol and aqueous extracts of Nerium indicum were obtained by simple maceration method and subjected to standardization by following pharmacognostical and phytochemical screening methods. Dose selection was made on the basis of acute oral toxicity study (50mg to 5000 mg/kg body weight) as per OECD guidelines. Nerium indicum chloroform extract (NICE) and ethanolic extract (NIEE) showed signiÞ cant (P