Phytochemical analysis and antibacterial activity of Vitex agnus-castus

Phytochemical analysis and antibacterial activity of Vitex agnus-castus

The leaves of Vitex agnus-castus was sequentially extracted in hexane, ethyl acetate, methanol and aqueous medium and studied for in vitro antibacterial property. The ethyl acetate extract was found to be most active against all the bacterial species tested except K. pneumoniae. The best MIC value (...

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Veröffentlicht in:International journal of green pharmacy 2009-04, Vol.3 (2), p.162
Hauptverfasser: Arokiyaraj, S, Perinbam, K, Agastian, P, Kumar, RMohan
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Antibacterial agents
Antimicrobial agents
Bacteria
Bacterial infections
Care and treatment
Comparative analysis
E coli
Folk medicine
Health aspects
Materia medica, Vegetable
Metabolites
Microbiology
Microorganisms
Natural products
Pharmaceutical industry
Phytochemicals
Plant extracts
Staphylococcus infections
Vitex
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Zusammenfassung:The leaves of Vitex agnus-castus was sequentially extracted in hexane, ethyl acetate, methanol and aqueous medium and studied for in vitro antibacterial property. The ethyl acetate extract was found to be most active against all the bacterial species tested except K. pneumoniae. The best MIC value (0.312 mg/ml) was seen against MRSA. Active ethyl acetate extract was further studied for HPTLC fingerprint and phytochemical analysis. HPTLC analysis confirmed segregation of eight individual compounds with individual Rf values and peak area percentage. The results of phytochemical screening of extract revealed the presence of terpenoids, steroids, flavonoids and carbohydrates. This analysis revealed the high antibacterial activity in active ethyl acetate from Vitex agnus- castus.
ISSN:0973-8258
1998-4103
DOI:10.4103/0973-8258.54912