p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors

p16 Ink4a is a protein involved in regulation of the cell cycle. Currently, p16 Ink4a is considered a tumor suppressor protein because of its physiological role and downregulated expression in a large number of tumors. Intriguingly, overexpression of p16 Ink4a has also been described in several tumo...

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Veröffentlicht in:	Oncogene 2011-05, Vol.30 (18), p.2087-2097
Hauptverfasser:	Romagosa, C, Simonetti, S, López-Vicente, L, Mazo, A, Lleonart, M E, Castellvi, J, Ramon y Cajal, S
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/581 631/80/509 692/700/1750 Apoptosis Biological and medical sciences Cancer Cell Biology Cell cycle Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Fundamental and applied biological sciences. Psychology Gene expression Human Genetics INK4a protein Internal Medicine Medicine Medicine & Public Health Molecular and cellular biology Oncology p16 Protein Proteins review Senescence Tumor suppressor genes Tumors
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Beschreibung
Zusammenfassung:	p16 Ink4a is a protein involved in regulation of the cell cycle. Currently, p16 Ink4a is considered a tumor suppressor protein because of its physiological role and downregulated expression in a large number of tumors. Intriguingly, overexpression of p16 Ink4a has also been described in several tumors. This review attempts to elucidate when and why p16 Ink4a overexpression occurs, and to suggest possible implications of p16 Ink4a in the diagnosis, prognosis and treatment of cancer.
ISSN:	0950-9232 1476-5594
DOI:	10.1038/onc.2010.614