Ionol (BHT) produces superoxide anion

Ionol (BHT) produces superoxide anion

In aqueous medium etiolated wheat seedlings release superoxide anion (O2*-). Interaction of a synthetic antioxidant, butylated hydroxytoluene (BHT, ionol), with oxygen in the aqueous medium is accompanied by O2*- formation. This suggests that under certain conditions BHT behaves as a prooxidant. A n...

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Veröffentlicht in:Biochemistry (Moscow) 2002-11, Vol.67 (11), p.1271
Hauptverfasser: Smirnova, E G, Lyubimov, Yu I, Malinina, T G, Lyubimova, E Yu, Alexandrushkina, N I, Vanyushin, B F, Kolesova, G M, Yaguzhinsky, L S
Format: Artikel
Sprache:eng
Schlagworte:
Antioxidants - pharmacology
Butylated Hydroxytoluene - chemistry
Butylated Hydroxytoluene - pharmacology
Kinetics
Oxidants - pharmacology
Oxygen - chemistry
Placenta - chemistry
Seeds - drug effects
Seeds - metabolism
Superoxide Dismutase - pharmacology
Superoxides - metabolism
Triticum - drug effects
Triticum - metabolism
Water - chemistry
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Zusammenfassung:In aqueous medium etiolated wheat seedlings release superoxide anion (O2*-). Interaction of a synthetic antioxidant, butylated hydroxytoluene (BHT, ionol), with oxygen in the aqueous medium is accompanied by O2*- formation. This suggests that under certain conditions BHT behaves as a prooxidant. A natural antioxidant, superoxide dismutase (SOD), and also a wound healing preparation, emulsified denatured placenta (EDP), do not exhibit the prooxidant properties. In contrast to BHT, they reduce O2*- production by the etiolated wheat seedling system.
ISSN:0006-2979
1608-3040
DOI:10.1023/A:1021357506703