Experimental Molecular Design of Combined Vaccines

Experimental Molecular Design of Combined Vaccines

A method was elaborated to construct combined artificial immunogens simulating virus particles. The gist was exposing protein antigenic determinants of one virus on the particle surface and delivering plasmids with genes for antigenic proteins of another virus to specialized immune cells. Such immun...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecular biology (New York) 2003-05, Vol.37 (3), p.464
Hauptverfasser: Lebedev, L R, Goncharova, E P, Sizov, A A, Bulychev, L E, Odegov, A M, Ryzhikov, A B
Format: Artikel
Sprache:eng
Schlagworte:
Immunology
Viruses
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 3
container_start_page 464
container_title Molecular biology (New York)
container_volume 37
creator Lebedev, L R
Goncharova, E P
Sizov, A A
Bulychev, L E
Odegov, A M
Ryzhikov, A B
description A method was elaborated to construct combined artificial immunogens simulating virus particles. The gist was exposing protein antigenic determinants of one virus on the particle surface and delivering plasmids with genes for antigenic proteins of another virus to specialized immune cells. Such immunogens were constructed and shown to induce biosynthesis of specific antibodies against HIV-1 and the tick-borne encephalitis virus. The level and duration of the humoral and cell responses were assayed.[PUBLICATION ABSTRACT]
doi_str_mv 10.1023/A:1024255814811
format Article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_760111725</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2173841371</sourcerecordid><originalsourceid>FETCH-LOGICAL-p180t-f9b671f914ae445da90db9335676f70e2bb0d4e68ed1077c1c97ae3c913696cf3</originalsourceid><addsrcrecordid>eNotjktLw0AUhQdRMFbXboP76L3zHncl1gdUuqluy2RyR1LSJGYS8OcbUDjwndV3DmO3CPcIXDysHxdIrpRFaRHPWIYabCG4VOcsA-C6sE6IS3aV0hEAl_CM8c3PQGNzom7ybf7etxTm1o_5E6Xmq8v7mJf9qWo6qvNPH8JS0jW7iL5NdPPPFft43uzL12K7e3kr19tiQAtTEV2lDUaH0pOUqvYO6mo5oLTR0QDxqoJakrZUIxgTMDjjSQSHQjsdolixuz_vMPbfM6XpcOznsVsmD0YDIhquxC-Hg0VB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>760111725</pqid></control><display><type>article</type><title>Experimental Molecular Design of Combined Vaccines</title><source>Springer Nature - Complete Springer Journals</source><creator>Lebedev, L R ; Goncharova, E P ; Sizov, A A ; Bulychev, L E ; Odegov, A M ; Ryzhikov, A B</creator><creatorcontrib>Lebedev, L R ; Goncharova, E P ; Sizov, A A ; Bulychev, L E ; Odegov, A M ; Ryzhikov, A B</creatorcontrib><description>A method was elaborated to construct combined artificial immunogens simulating virus particles. The gist was exposing protein antigenic determinants of one virus on the particle surface and delivering plasmids with genes for antigenic proteins of another virus to specialized immune cells. Such immunogens were constructed and shown to induce biosynthesis of specific antibodies against HIV-1 and the tick-borne encephalitis virus. The level and duration of the humoral and cell responses were assayed.[PUBLICATION ABSTRACT]</description><identifier>ISSN: 0026-8933</identifier><identifier>EISSN: 1608-3245</identifier><identifier>DOI: 10.1023/A:1024255814811</identifier><language>eng</language><publisher>New York: Springer Nature B.V</publisher><subject>Immunology ; Viruses</subject><ispartof>Molecular biology (New York), 2003-05, Vol.37 (3), p.464</ispartof><rights>MAIK "Nauka/Interperiodica" 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Lebedev, L R</creatorcontrib><creatorcontrib>Goncharova, E P</creatorcontrib><creatorcontrib>Sizov, A A</creatorcontrib><creatorcontrib>Bulychev, L E</creatorcontrib><creatorcontrib>Odegov, A M</creatorcontrib><creatorcontrib>Ryzhikov, A B</creatorcontrib><title>Experimental Molecular Design of Combined Vaccines</title><title>Molecular biology (New York)</title><description>A method was elaborated to construct combined artificial immunogens simulating virus particles. The gist was exposing protein antigenic determinants of one virus on the particle surface and delivering plasmids with genes for antigenic proteins of another virus to specialized immune cells. Such immunogens were constructed and shown to induce biosynthesis of specific antibodies against HIV-1 and the tick-borne encephalitis virus. The level and duration of the humoral and cell responses were assayed.[PUBLICATION ABSTRACT]</description><subject>Immunology</subject><subject>Viruses</subject><issn>0026-8933</issn><issn>1608-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNotjktLw0AUhQdRMFbXboP76L3zHncl1gdUuqluy2RyR1LSJGYS8OcbUDjwndV3DmO3CPcIXDysHxdIrpRFaRHPWIYabCG4VOcsA-C6sE6IS3aV0hEAl_CM8c3PQGNzom7ybf7etxTm1o_5E6Xmq8v7mJf9qWo6qvNPH8JS0jW7iL5NdPPPFft43uzL12K7e3kr19tiQAtTEV2lDUaH0pOUqvYO6mo5oLTR0QDxqoJakrZUIxgTMDjjSQSHQjsdolixuz_vMPbfM6XpcOznsVsmD0YDIhquxC-Hg0VB</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Lebedev, L R</creator><creator>Goncharova, E P</creator><creator>Sizov, A A</creator><creator>Bulychev, L E</creator><creator>Odegov, A M</creator><creator>Ryzhikov, A B</creator><general>Springer Nature B.V</general><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20030501</creationdate><title>Experimental Molecular Design of Combined Vaccines</title><author>Lebedev, L R ; Goncharova, E P ; Sizov, A A ; Bulychev, L E ; Odegov, A M ; Ryzhikov, A B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p180t-f9b671f914ae445da90db9335676f70e2bb0d4e68ed1077c1c97ae3c913696cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Immunology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lebedev, L R</creatorcontrib><creatorcontrib>Goncharova, E P</creatorcontrib><creatorcontrib>Sizov, A A</creatorcontrib><creatorcontrib>Bulychev, L E</creatorcontrib><creatorcontrib>Odegov, A M</creatorcontrib><creatorcontrib>Ryzhikov, A B</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health &amp; Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health &amp; Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied &amp; Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Molecular biology (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lebedev, L R</au><au>Goncharova, E P</au><au>Sizov, A A</au><au>Bulychev, L E</au><au>Odegov, A M</au><au>Ryzhikov, A B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental Molecular Design of Combined Vaccines</atitle><jtitle>Molecular biology (New York)</jtitle><date>2003-05-01</date><risdate>2003</risdate><volume>37</volume><issue>3</issue><spage>464</spage><pages>464-</pages><issn>0026-8933</issn><eissn>1608-3245</eissn><abstract>A method was elaborated to construct combined artificial immunogens simulating virus particles. The gist was exposing protein antigenic determinants of one virus on the particle surface and delivering plasmids with genes for antigenic proteins of another virus to specialized immune cells. Such immunogens were constructed and shown to induce biosynthesis of specific antibodies against HIV-1 and the tick-borne encephalitis virus. The level and duration of the humoral and cell responses were assayed.[PUBLICATION ABSTRACT]</abstract><cop>New York</cop><pub>Springer Nature B.V</pub><doi>10.1023/A:1024255814811</doi></addata></record>
fulltext fulltext
identifier ISSN: 0026-8933
ispartof Molecular biology (New York), 2003-05, Vol.37 (3), p.464
issn 0026-8933
1608-3245
language eng
recordid cdi_proquest_journals_760111725
source Springer Nature - Complete Springer Journals
subjects Immunology
Viruses
title Experimental Molecular Design of Combined Vaccines
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T22%3A45%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Experimental%20Molecular%20Design%20of%20Combined%20Vaccines&rft.jtitle=Molecular%20biology%20(New%20York)&rft.au=Lebedev,%20L%20R&rft.date=2003-05-01&rft.volume=37&rft.issue=3&rft.spage=464&rft.pages=464-&rft.issn=0026-8933&rft.eissn=1608-3245&rft_id=info:doi/10.1023/A:1024255814811&rft_dat=%3Cproquest%3E2173841371%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=760111725&rft_id=info:pmid/&rfr_iscdi=true