Experimental Molecular Design of Combined Vaccines

Experimental Molecular Design of Combined Vaccines

A method was elaborated to construct combined artificial immunogens simulating virus particles. The gist was exposing protein antigenic determinants of one virus on the particle surface and delivering plasmids with genes for antigenic proteins of another virus to specialized immune cells. Such immun...

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Veröffentlicht in:Molecular biology (New York) 2003-05, Vol.37 (3), p.464
Hauptverfasser: Lebedev, L R, Goncharova, E P, Sizov, A A, Bulychev, L E, Odegov, A M, Ryzhikov, A B
Format: Artikel
Sprache:eng
Schlagworte:
Immunology
Viruses
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Zusammenfassung:A method was elaborated to construct combined artificial immunogens simulating virus particles. The gist was exposing protein antigenic determinants of one virus on the particle surface and delivering plasmids with genes for antigenic proteins of another virus to specialized immune cells. Such immunogens were constructed and shown to induce biosynthesis of specific antibodies against HIV-1 and the tick-borne encephalitis virus. The level and duration of the humoral and cell responses were assayed.[PUBLICATION ABSTRACT]
ISSN:0026-8933
1608-3245
DOI:10.1023/A:1024255814811