24-h Intraocular pressure control with evening-dosed travoprost timolol, compared with latanoprost timolol, fixed combinations in exfoliative glaucoma

Purpose To evaluate 24-h efficacy of travoprost/timolol fixed combination (TTFC) vs latanoprost/timolol fixed combination (LTFC) in exfoliative glaucoma (XFG). Design A prospective, single-masked, crossover, active-controlled, randomized 24-h comparison. Methods After up to a 6-week medicine-free period, XFG patients were randomized to either TTFC or LTFC for 3 months, dosed each evening, and then changed to the opposite treatment for another 3 months. At the end of the washout, and both treatment periods, a 24-h intraocular pressure (IOP) curve was measured. Results In total, 40 patients completed the study. The TTFC group showed a lower mean absolute 24-h IOP (18.7±2.6 vs 19.6±2.6 mm Hg, P