Some unsolved problems and unresolved issues in radiation cytogenetics: A review and new data on roles of homologous recombination and nonhomologous end joining

New data and historical evidence from our own and other laboratories are summarized and discussed bearing on several issues relating to mechanisms and processes involved in the formation of chromosomal aberrations following exposure to ionizing radiations. Specifically addressed are: (1) the lesions...

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Veröffentlicht in:Mutation research. Genetic toxicology and environmental mutagenesis 2010-08, Vol.701 (1), p.12
Hauptverfasser: Nagasawa, Hatsumi, Brogan, John R, Peng, Yuanlin, Little, John B, Bedford, Joel S
Format: Artikel
Sprache:eng
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Zusammenfassung:New data and historical evidence from our own and other laboratories are summarized and discussed bearing on several issues relating to mechanisms and processes involved in the formation of chromosomal aberrations following exposure to ionizing radiations. Specifically addressed are: (1) the lesions and processes affecting the appearance of chromatid-type and/or chromosome-type aberrations after radiation, (2) DNA double strand break rejoining processes and the restitution of breaks vs. the formation of exchanges, (3) the role of homologous recombinational repair in protecting cells from induction of chromatid-type aberrations after irradiation of late S/G2 cells, (4) the role of interphase chromatin structure and nuclear organization in aberration induction, (5) cellular responses for aberration induction in relation to their tissue context, and (6) approaches to the detection of aberrations previously known as "cryptic". [PUBLICATION ABSTRACT]
ISSN:1383-5718
1879-3592