Observed exoplanets and intelligent life

If intelligent life were common in the Universe, should we not be aware of it on Earth through contact with advanced space ships and automatic probes? Would we not at least expect to intercept communication signals between space travellers? That this is not found has led to much speculation in the past. Recent discoveries of planets around other stars (called here exoplanets) and, separately, recent discoveries in the evolution of life on Earth, including Homo sapiens, allow this question to be considered again but now with more information than before. This is the subject of the present paper. The study involves aspects of physics and chemistry in combination with biological studies. It is concluded here that the places where technologically capable intelligent life might be expected to be found in our Galaxy are so few that any such "centres of civilisation" must be separated by large distances, probably in excess of 50 light years. If true, this would make the different centres essentially isolated and would suggest that each manifestation of advanced intelligent life is a purely local development. This would agree with our experience of aloneness. Nevertheless, the number of centres throughout the Universe would still be astronomically large, even if each galaxy had only one centre. An hypothesis is proposed which could account for the existence of such centres in this form.[PUBLICATION ABSTRACT]