Relationship between body iron stores and diquat toxicity in male Fischer-344 rats

Relationship between body iron stores and diquat toxicity in male Fischer-344 rats

The effects of body iron stores on diquat (DQ)-induced toxicity were examined in male Fischer-344 rats, which are sensitive to this herbicide. The rats (5 weeks old) were fed diets containing 40 (lower iron storage [LIS] group) or 320 ppm iron (higher iron storage [HIS] group) for 5 weeks. The conce...

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Veröffentlicht in:Biometals 2006-12, Vol.19 (6), p.651-657
Hauptverfasser: Abe, Teruhisa, Kinda, Takasuke, Takano, Yasushi, Chikazawa, Seishiro, Higuchi, Masashi, Kawasaki, Naomi, Orino, Koichi, Watanabe, Kiyotaka
Format: Artikel
Sprache:eng
Schlagworte:
Alanine Transaminase - blood
Anemia
Animals
Blood Urea Nitrogen
Diquat
Diquat - toxicity
Ferritins - metabolism
Injection
Iron
Iron - metabolism
Iron, Dietary - administration & dosage
Kidney - drug effects
Liver - drug effects
Male
Nonheme Iron Proteins - analysis
Rats
Rats, Inbred F344
Survival Analysis
Toxicity
Urea
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Zusammenfassung:The effects of body iron stores on diquat (DQ)-induced toxicity were examined in male Fischer-344 rats, which are sensitive to this herbicide. The rats (5 weeks old) were fed diets containing 40 (lower iron storage [LIS] group) or 320 ppm iron (higher iron storage [HIS] group) for 5 weeks. The concentrations of nonheme iron and ferritin in the liver and kidney were significantly higher in the HIS group than in the LIS group (P
ISSN:0966-0844
1572-8773
DOI:10.1007/s10534-006-9002-6