Indomethacin Corrects Alterations Associated with Ischemia/Reperfusion in an in vitro Proximal Tubular Model

Background/Aims: Recent in vivo data indicate that indomethacin improves renal outcome after ischemia via improvement of renal cell survival and function. To examine direct effects of indomethacin on isolated proximal tubular cells, we investigated the influence of indomethacin on markers of ischemi...

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Veröffentlicht in:	American journal of nephrology 2010-01, Vol.32 (1), p.57-65
Hauptverfasser:	Sauvant, C., Schneider, R., Holzinger, H., Renker, S., Wanner, C., Gekle, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biomarkers Cardiovascular Agents - pharmacology Cells, Cultured Chemokine CCL2 - genetics Dinoprostone - metabolism Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Extracellular Matrix - drug effects Extracellular Matrix - pathology In Vitro Techniques Indomethacin - pharmacology Kidney Tubules, Proximal - cytology Necrosis NF-kappa B - metabolism Nitric Oxide Synthase Type II - genetics Opossums Organic Anion Transporters - metabolism Original Report: Laboratory Investigation Rats Reperfusion Injury - drug therapy Reperfusion Injury - pathology RNA, Messenger - metabolism
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