Distinct patterns of brain activity in young carriers of the APOE e4 allele

Distinct patterns of brain activity in young carriers of the APOE e4 allele

[...]BOLD fMRI emerges as the most sensitive measure of genotypic differences. [...]these data indicate that the APOE [epsilon]4 allelic variant modulates brain function decades before any clinical or neurophysiological expression of neurodegenerative processes.

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Bibliographische Detailangaben
Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2009-07, Vol.47, p.S139-S139
Hauptverfasser: Filippini, N, MacIntosh, BJ, Hough, MG, Goodwin, GM, Frisoni, GB, Ebmeier, K, Smith, S, Matthews, PM, Beckmann, CF, Mackay, CE
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer's disease
Apolipoprotein E4
Morphology
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Zusammenfassung:[...]BOLD fMRI emerges as the most sensitive measure of genotypic differences. [...]these data indicate that the APOE [epsilon]4 allelic variant modulates brain function decades before any clinical or neurophysiological expression of neurodegenerative processes.
ISSN:1053-8119
1095-9572
DOI:10.1016/S1053-8119(09)71381-3