Enantioselective addition of 3-hydroxyquinolin-2(1 H )-one to isatin and pyrazole-4,5-dione derived ketimines
The enantioselective reactivity of 3-hydroxyquinolin-2(1 H )-ones was developed through their addition to isatin and pyrazole-4,5-dione derived ketimines, affording novel architectures featuring multiple natural product scaffolds in high yields with excellent enantioselectivities. Gram-scale synthes...
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| Veröffentlicht in: | Organic Chemistry Frontiers 2025-01, Vol.12 (2), p.497-502 |
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| container_end_page | 502 |
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| container_issue | 2 |
| container_start_page | 497 |
| container_title | Organic Chemistry Frontiers |
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| creator | Wei, Yue Bai, Guishun Wu, Jiamin Hua, Yi Zhang, Tao Yue, Congyong Wang, Hong Bao, Xiaoze |
| description | The enantioselective reactivity of 3-hydroxyquinolin-2(1 H )-ones was developed through their addition to isatin and pyrazole-4,5-dione derived ketimines, affording novel architectures featuring multiple natural product scaffolds in high yields with excellent enantioselectivities. Gram-scale synthesis and synthetic transformations further disclosed the potential of the current process. |
| doi_str_mv | 10.1039/D4QO01895H |
| format | Article |
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| identifier | ISSN: 2052-4129 |
| ispartof | Organic Chemistry Frontiers, 2025-01, Vol.12 (2), p.497-502 |
| issn | 2052-4129 2052-4110 2052-4129 2052-4110 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Enantiomers Imines Natural products Pyrazole Pyrazoles |
| title | Enantioselective addition of 3-hydroxyquinolin-2(1 H )-one to isatin and pyrazole-4,5-dione derived ketimines |
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