Enantioselective addition of 3-hydroxyquinolin-2(1 H )-one to isatin and pyrazole-4,5-dione derived ketimines

Enantioselective addition of 3-hydroxyquinolin-2(1 H )-one to isatin and pyrazole-4,5-dione derived ketimines

The enantioselective reactivity of 3-hydroxyquinolin-2(1 H )-ones was developed through their addition to isatin and pyrazole-4,5-dione derived ketimines, affording novel architectures featuring multiple natural product scaffolds in high yields with excellent enantioselectivities. Gram-scale synthes...

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Veröffentlicht in:Organic Chemistry Frontiers 2025-01, Vol.12 (2), p.497-502
Hauptverfasser: Wei, Yue, Bai, Guishun, Wu, Jiamin, Hua, Yi, Zhang, Tao, Yue, Congyong, Wang, Hong, Bao, Xiaoze
Format: Artikel
Sprache:eng
Schlagworte:
Enantiomers
Imines
Natural products
Pyrazole
Pyrazoles
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Zusammenfassung:The enantioselective reactivity of 3-hydroxyquinolin-2(1 H )-ones was developed through their addition to isatin and pyrazole-4,5-dione derived ketimines, affording novel architectures featuring multiple natural product scaffolds in high yields with excellent enantioselectivities. Gram-scale synthesis and synthetic transformations further disclosed the potential of the current process.
ISSN:2052-4129
2052-4110
2052-4129
2052-4110
DOI:10.1039/D4QO01895H