Iron‐Catalyzed Cross‐Coupling Reactions of Alkyl Grignard Reagents with Alkenyl Carbonate

Iron‐Catalyzed Cross‐Coupling Reactions of Alkyl Grignard Reagents with Alkenyl Carbonate

Herein, we report the alkylation of alkenyl carbonates using alkyl Grignard reagents and iron catalysis to generate C(sp2)−C(sp3) bonds and provide synthetically useful yields over a range of substrates. The transformation allows the alkylation of a wide range of substrates, including aromatic rings...

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Veröffentlicht in:Advanced synthesis & catalysis 2024-10, Vol.366 (24), p.5026-5032
Hauptverfasser: Qin, Hongjian, Yang, Xingbang, Mintah Bonku, Emmanuel, Zhu, Fuqiang, Abduahadi, Safomuddin, Yang, Peng, Shen, Jingshan, Akber Aisa, Haji
Format: Artikel
Sprache:eng
Schlagworte:
Alkanes
Alkylation
Alkylation of alkenyl carbonates
Aromatic compounds
C(sp2)−C(sp3) bonds formation
Carbonates
Chemical reactions
Cross coupling
Cross-coupling reactions
Grignard reagents
Iron
Iron catalysis
Reagents
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Zusammenfassung:Herein, we report the alkylation of alkenyl carbonates using alkyl Grignard reagents and iron catalysis to generate C(sp2)−C(sp3) bonds and provide synthetically useful yields over a range of substrates. The transformation allows the alkylation of a wide range of substrates, including aromatic rings, alkanes, cycloalkanes, heterocycles. This reaction has introduced a new family of electrophiles to the iron‐catalyzed cross‐coupling reactions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202400979