Systemic Administration of Neurotransmitter‐Derived Lipidoids‐PROTACs‐DNA Nanocomplex Promotes Tau Clearance and Cognitive Recovery for Alzheimer's Disease Therapy (Adv. Healthcare Mater. 32/2024)

Alzheimer's Disease Upon systemic administration of NPD via tail vein injection, NPD effectively penetrated the bloodbrain barrier and delivered proteolysis‐targeting chimera (PROTAC), to the intracranial lesions. At where, PROTACs bridged TAU and KEAP1 that induced tau ubiquitination and degra...

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Veröffentlicht in:	Advanced healthcare materials 2024-12, Vol.13 (32), p.n/a
Hauptverfasser:	Gong, Baofeng, Zhang, Weicong, Cong, Wei, Gu, Yuankai, Ji, Wenbo, Yin, Tong, Zhou, Honglei, Hu, Honggang, Zhuang, Jianhua, Luo, Yi, Liu, Yan, Gao, Jie, Yin, You
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Chimeras Neurodegenerative diseases Proteolysis Tau protein Ubiquitination
Online-Zugang:	Volltext
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