Systemic Administration of Neurotransmitter‐Derived Lipidoids‐PROTACs‐DNA Nanocomplex Promotes Tau Clearance and Cognitive Recovery for Alzheimer's Disease Therapy (Adv. Healthcare Mater. 32/2024)

Alzheimer's Disease Upon systemic administration of NPD via tail vein injection, NPD effectively penetrated the bloodbrain barrier and delivered proteolysis‐targeting chimera (PROTAC), to the intracranial lesions. At where, PROTACs bridged TAU and KEAP1 that induced tau ubiquitination and degradation through the UPS, in turn, improved the function of neurons, and prevented and treated Alzheimer's disease. More details can be found in article 2300149 by Yi Luo, Yan Liu, Jie Gao, You Yin, and co‐workers.