Novel Acylhydrazones Based on 1-Decylisatins and Girard Reagent T Possessing Antimicrobial Activity
By the reaction of new 1-decyl substituted isatin derivatives with Girard reagent T novel ammonium salts were obtained. These compounds display a moderate antimicrobial activity against gram-positive Staphylococcus aureus and Bacillus cereus bacterial strains with low hemotoxicity. Study of the infl...
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| Veröffentlicht in: | Russian journal of general chemistry 2024-11, Vol.94 (11), p.3099-3103 |
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| container_title | Russian journal of general chemistry |
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| creator | Bogdanov, A. V. Voloshina, A. D. Il’in, A. V. Kadomtseva, M. E. Pashirova, T. N. Shaihutdinova, Z. M. Mironov, V. F. |
| description | By the reaction of new 1-decyl substituted isatin derivatives with Girard reagent T novel ammonium salts were obtained. These compounds display a moderate antimicrobial activity against gram-positive
Staphylococcus aureus
and
Bacillus cereus
bacterial strains with low hemotoxicity. Study of the influence of the structure of substituents in the heterocycle aromatic fragment on the self-assembly process and antimicrobial activity may indirectly indicate that the antimicrobial action of amphiphilic ammonium compounds based on the isatin scaffold is different from classical cationic surfactants. |
| doi_str_mv | 10.1134/S1070363224110331 |
| format | Article |
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Staphylococcus aureus
and
Bacillus cereus
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Staphylococcus aureus
and
Bacillus cereus
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Staphylococcus aureus
and
Bacillus cereus
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| subjects | Ammonium compounds Aromatic compounds Chemistry Chemistry and Materials Science Chemistry/Food Science Reagents Self-assembly |
| title | Novel Acylhydrazones Based on 1-Decylisatins and Girard Reagent T Possessing Antimicrobial Activity |
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