Novel Acylhydrazones Based on 1-Decylisatins and Girard Reagent T Possessing Antimicrobial Activity

By the reaction of new 1-decyl substituted isatin derivatives with Girard reagent T novel ammonium salts were obtained. These compounds display a moderate antimicrobial activity against gram-positive Staphylococcus aureus and Bacillus cereus bacterial strains with low hemotoxicity. Study of the influence of the structure of substituents in the heterocycle aromatic fragment on the self-assembly process and antimicrobial activity may indirectly indicate that the antimicrobial action of amphiphilic ammonium compounds based on the isatin scaffold is different from classical cationic surfactants.