A Pan-Cancer Analysis of the Oncogenic Role of Methyltransferase-Like 1 in Human Tumors

Although emerging cell- or animal-based evidence supports the relationship between methyltransferase-like 1 (METTL1) and cancers, no pan-cancer analysis is available. We thus first explored the potential oncogenic roles of METTL1 across 33 tumors based on the datasets of The Cancer Genome Atlas and Gene Expression Omnibus. METTL1 is highly expressed in most cancers, and distinct associations exist between METTL1 expression and prognosis of tumor patients. METTL1 level is related with the dendritic and B-cell infiltration levels in most tumors. Moreover, RNA processing- and RNA metabolism-associated functions were involved in the functional mechanisms of METTL1. Our pan-cancer study offers a relatively comprehensive understanding of the oncogenic roles of METTL1 across different tumors.