Practical Application of Multivendor MRI‐Based R2 Mapping for Liver Iron Quantification at 1.5T and 3.0T

BackgroundRecent multicenter, multivendor MRI‐based R2* vs. liver iron concentration (LIC) calibrations (i.e., MCMV calibrations) may facilitate broad clinical dissemination of R2*‐based LIC quantification. However, these calibrations are based on a centralized offline R2* reconstruction, and their applicability with vendor‐provided R2* maps is unclear.PurposeTo determine R2* ranges of agreement between the centralized and three MRI vendors' R2* reconstructions.Study TypeProspective.SubjectsTwo hundred and seven subjects (mean age 37.6 ± 19.6 years; 117 male) with known or suspected iron overload from four academic medical centers.Field Strength/SequenceStandardized multiecho spoiled gradient echo sequence at 1.5 T and 3.0 T for R2* mapping and a multiple spin‐echo sequence at 1.5 T for LIC quantification. MRI vendors: GE Healthcare, Philips Healthcare, and Siemens Healthineers.AssessmentR2* maps were generated using both the centralized and vendor reconstructions, and ranges of agreement were determined. R2*‐LIC linear calibrations were determined for each site, field strength, and reconstruction and compared with the MCMV calibrations.Statistical TestsBland–Altman analysis to determine ranges of agreement. Linear regression, analysis of covariance F tests, and Tukey's multiple comparison testing to assess reproducibility of calibrations across sites and vendors. A P value