Safety and efficacy of non-surgical treatments for chronic post-radiation cystitis: a systematic review

According to Westerman et al., about two-thirds of patients experienced remission of post-radiation cystitis symptoms, and one-third of those maintained these results, suggesting its efficacy as first-line treatment [12]. When silver nitrate is mixed with water nitric acid is produced, which has cauterising properties [19]. Since most relevant studies were carried out in children with haemorrhagic cystitis caused by cyclophosphamide, silver nitrate plays a limited role in the management of adults with haemorrhagic cystitis [20-22]. MATERIAL AND METHODS Study characteristics This is a systematic review of the literature from the first recorded report on chronic post-radiation cystitis up to December 2023, aimed at finding all papers that meet the inclusion criteria. Inclusion and exclusion criteria For a study to be included in this systematic review it had to involve adult patients with symptoms of chronic post-radiation cystitis, presence of symptoms for 6 months after the end of radiotherapy, or persistence of symptoms for more than 6 months.