Analysis of monocyte chemoattractant protein-1 and interleukin-1β levels with adrenocorticotropic hormone levels in farmers: early detection of vascular inflammation due to pesticide exposure
Pesticides have a severe impact on environmental pollution and human health, causing significant self-poisoning deaths in low- and middle-income countries. This study examines inflammation in farmers due to pesticide exposure by measuring MCP-1, IL-1β, and levels of ACTH. Using a cross-sectional des...
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| Veröffentlicht in: | Environmental pollutants & bioavailability 2024-12, Vol.36 (1) |
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| creator | Kumboyono, Kumboyono Chomsy, Indah Nur Rachmawati, Septi Dewi Hayati, Yati Sri Setiawan, Meddy Hakim, Ardhi Khoirul Wihastuti, Titin Andri |
| description | Pesticides have a severe impact on environmental pollution and human health, causing significant self-poisoning deaths in low- and middle-income countries. This study examines inflammation in farmers due to pesticide exposure by measuring MCP-1, IL-1β, and levels of ACTH. Using a cross-sectional design, 312 participants from conventional and organic farmer groups in Dau District, Malang Regency, were randomly selected. Results showed IL-1β levels were 633.29 ± 33.20 pg/mL in conventional farmers and 308.52 ± 65.18 pg/L in organic farmers (p |
| doi_str_mv | 10.1080/26395940.2024.2391352 |
| format | Article |
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This study examines inflammation in farmers due to pesticide exposure by measuring MCP-1, IL-1β, and levels of ACTH. Using a cross-sectional design, 312 participants from conventional and organic farmer groups in Dau District, Malang Regency, were randomly selected. Results showed IL-1β levels were 633.29 ± 33.20 pg/mL in conventional farmers and 308.52 ± 65.18 pg/L in organic farmers (p < 0.001), MCP-1 levels were 506.58 ± 75.24 and 141.19 ± 39.19 pg/L, and ACTH levels were 456.64 ± 118.34 pg/L and 61.09 ± 15.98 pg/L, respectively (p < 0.001). These findings suggest that pesticide exposure induces vascular inflammation, evidenced by increased inflammatory markers in conventional farmers.</description><identifier>ISSN: 2639-5932</identifier><identifier>EISSN: 2639-5940</identifier><identifier>DOI: 10.1080/26395940.2024.2391352</identifier><language>eng</language><publisher>Abingdon: Taylor & Francis Ltd</publisher><subject>Adrenocorticotropic hormone ; Agriculture ; Body mass index ; Chemokines ; Cytokines ; Diabetes ; Disease ; Environmental health ; Environmental impact ; Exposure ; Farmers ; Fluorides ; Fungicides ; Health sciences ; Herbicides ; Hormones ; IL-1β ; Immune system ; Impact analysis ; Inflammation ; Insecticides ; Medical research ; Monocyte chemoattractant protein ; Monocyte chemoattractant protein 1 ; Monocytes ; Nursing ; Organic farming ; Pesticides ; Pollution detection ; Proteins</subject><ispartof>Environmental pollutants & bioavailability, 2024-12, Vol.36 (1)</ispartof><rights>2024 The Author(s). 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| subjects | Adrenocorticotropic hormone Agriculture Body mass index Chemokines Cytokines Diabetes Disease Environmental health Environmental impact Exposure Farmers Fluorides Fungicides Health sciences Herbicides Hormones IL-1β Immune system Impact analysis Inflammation Insecticides Medical research Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Nursing Organic farming Pesticides Pollution detection Proteins |
| title | Analysis of monocyte chemoattractant protein-1 and interleukin-1β levels with adrenocorticotropic hormone levels in farmers: early detection of vascular inflammation due to pesticide exposure |
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