99mTc-radiolabeling of a functionalized Carum carvi-derived quantum dots (CcQDs) as a new radiotracer for CT26 colon carcinoma tumor targeting in mouse

Carum carvi-derived quantum dots (CcQDs) were prepared using thermal pyrolyzing. The surface functionalization of CcQDs were achieved via L-cysteine ligand. Labeled CcQDs with technetium-99m were prepared using a simple direct radiolabeling method. Radio chromatographic techniques were used to analyze radiochemical yield. Quality control results indicated that QDs could be efficiently labeled with 99m Tc-radionuclide (> 98% radiochemical yield). The in vivo biodistribution parameters were studied in tumorized BALB/c mouse. The amount of uptake in xenograft models of mice colon carcinoma was 1.27 ± 0.15% ID/g after 1 h. 99m Tc-labeled T-Cysteine-CcQDs, could be included as a radiotracer for imaging colon carcinoma tumors.