DNA Tetrahedron Delivering miR‐21‐5p Promotes Senescent Bone Defects Repair through Synergistic Regulation of Osteogenesis and Angiogenesis (Adv. Healthcare Mater. 30/2024)
Senescent Bone Repair The work constructed a TDN‐miR‐21‐5p nanocomplex based on DNA tetrahedral that promotes osteogenesis and alleviates senescence of O‐BMSCs, simultaneously enhances angiogenesis of O‐EPCs in vitro. In addition, TDN‐miR‐21‐5p@GelMA scaffold could promote senescent bone repair in v...
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| Veröffentlicht in: | Advanced healthcare materials 2024-12, Vol.13 (30), p.n/a |
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| creator | Qi, Lei Hong, Shebin Zhao, Tong Yan, Jinge Ge, Weiwen Wang, Jing Fang, Xin Jiang, Weidong Shen, Steve GF Zhang, Lei |
| description | Senescent Bone Repair
The work constructed a TDN‐miR‐21‐5p nanocomplex based on DNA tetrahedral that promotes osteogenesis and alleviates senescence of O‐BMSCs, simultaneously enhances angiogenesis of O‐EPCs in vitro. In addition, TDN‐miR‐21‐5p@GelMA scaffold could promote senescent bone repair in vivo, which provides a novel candidate strategy for senescent bone repair and widen clinical application of TDNs‐based gene therapy. More details can be found in article 2401275 by Weidong Jiang, Steve GF Shen, Lei Zhang, and co‐workers. |
| doi_str_mv | 10.1002/adhm.202470190 |
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The work constructed a TDN‐miR‐21‐5p nanocomplex based on DNA tetrahedral that promotes osteogenesis and alleviates senescence of O‐BMSCs, simultaneously enhances angiogenesis of O‐EPCs in vitro. In addition, TDN‐miR‐21‐5p@GelMA scaffold could promote senescent bone repair in vivo, which provides a novel candidate strategy for senescent bone repair and widen clinical application of TDNs‐based gene therapy. More details can be found in article 2401275 by Weidong Jiang, Steve GF Shen, Lei Zhang, and co‐workers.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202470190</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>Angiogenesis ; Bone healing ; Chromosome 5 ; Deoxyribonucleic acid ; DNA ; DNA repair ; Gene therapy ; Osteogenesis ; Senescence ; Tetrahedra</subject><ispartof>Advanced healthcare materials, 2024-12, Vol.13 (30), p.n/a</ispartof><rights>2024 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.202470190$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.202470190$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Qi, Lei</creatorcontrib><creatorcontrib>Hong, Shebin</creatorcontrib><creatorcontrib>Zhao, Tong</creatorcontrib><creatorcontrib>Yan, Jinge</creatorcontrib><creatorcontrib>Ge, Weiwen</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Fang, Xin</creatorcontrib><creatorcontrib>Jiang, Weidong</creatorcontrib><creatorcontrib>Shen, Steve GF</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><title>DNA Tetrahedron Delivering miR‐21‐5p Promotes Senescent Bone Defects Repair through Synergistic Regulation of Osteogenesis and Angiogenesis (Adv. Healthcare Mater. 30/2024)</title><title>Advanced healthcare materials</title><description>Senescent Bone Repair
The work constructed a TDN‐miR‐21‐5p nanocomplex based on DNA tetrahedral that promotes osteogenesis and alleviates senescence of O‐BMSCs, simultaneously enhances angiogenesis of O‐EPCs in vitro. In addition, TDN‐miR‐21‐5p@GelMA scaffold could promote senescent bone repair in vivo, which provides a novel candidate strategy for senescent bone repair and widen clinical application of TDNs‐based gene therapy. More details can be found in article 2401275 by Weidong Jiang, Steve GF Shen, Lei Zhang, and co‐workers.</description><subject>Angiogenesis</subject><subject>Bone healing</subject><subject>Chromosome 5</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA repair</subject><subject>Gene therapy</subject><subject>Osteogenesis</subject><subject>Senescence</subject><subject>Tetrahedra</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFUcFO20AQtaoiFQHXnlfqpRxiZtdZxz66BAgSlAro2Zrsju1Fzm66uwHlxifwKXwTX4KjVOHIHGZGM--90eglyXcOKQcQJ6i7RSpAjCfAS_iS7AteipHIZfl114_hW3IUwgMMkUueF3w_eZ3-rtg9RY8dae8sm1JvHskb27KFuX17fhF8SHLJ_ni3cJECuyNLQZGN7JezNBAaUjGwW1qi8Sx23q3ajt2tLfnWhGjUsGpXPUYzyLuG3YRIrt2ImMDQalbZ1uwGPyv9mLIZYR87hZ7YNUbyKcvgZPPe8WGy12Af6Oh_PUj-np_dn85GVzcXl6fV1UhxPoERFtDAHCdCcVBaakChC4FKosqllHOOmM8JxETKEqBUcpzjvMm1hkYVisrsIPmx1V16929FIdYPbuXtcLLOeFZyyAohB1S6RSnvQvDU1EtvFujXNYd6Y0y9MabeGTMQyi3hyfS0_gRdV9PZ9Qf3HeBVlJE</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Qi, Lei</creator><creator>Hong, Shebin</creator><creator>Zhao, Tong</creator><creator>Yan, Jinge</creator><creator>Ge, Weiwen</creator><creator>Wang, Jing</creator><creator>Fang, Xin</creator><creator>Jiang, Weidong</creator><creator>Shen, Steve GF</creator><creator>Zhang, Lei</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope></search><sort><creationdate>20241201</creationdate><title>DNA Tetrahedron Delivering miR‐21‐5p Promotes Senescent Bone Defects Repair through Synergistic Regulation of Osteogenesis and Angiogenesis (Adv. 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The work constructed a TDN‐miR‐21‐5p nanocomplex based on DNA tetrahedral that promotes osteogenesis and alleviates senescence of O‐BMSCs, simultaneously enhances angiogenesis of O‐EPCs in vitro. In addition, TDN‐miR‐21‐5p@GelMA scaffold could promote senescent bone repair in vivo, which provides a novel candidate strategy for senescent bone repair and widen clinical application of TDNs‐based gene therapy. More details can be found in article 2401275 by Weidong Jiang, Steve GF Shen, Lei Zhang, and co‐workers.</abstract><cop>Weinheim</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/adhm.202470190</doi><tpages>1</tpages></addata></record> |
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| subjects | Angiogenesis Bone healing Chromosome 5 Deoxyribonucleic acid DNA DNA repair Gene therapy Osteogenesis Senescence Tetrahedra |
| title | DNA Tetrahedron Delivering miR‐21‐5p Promotes Senescent Bone Defects Repair through Synergistic Regulation of Osteogenesis and Angiogenesis (Adv. Healthcare Mater. 30/2024) |
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