DNA Tetrahedron Delivering miR‐21‐5p Promotes Senescent Bone Defects Repair through Synergistic Regulation of Osteogenesis and Angiogenesis (Adv. Healthcare Mater. 30/2024)

Senescent Bone Repair The work constructed a TDN‐miR‐21‐5p nanocomplex based on DNA tetrahedral that promotes osteogenesis and alleviates senescence of O‐BMSCs, simultaneously enhances angiogenesis of O‐EPCs in vitro. In addition, TDN‐miR‐21‐5p@GelMA scaffold could promote senescent bone repair in vivo, which provides a novel candidate strategy for senescent bone repair and widen clinical application of TDNs‐based gene therapy. More details can be found in article 2401275 by Weidong Jiang, Steve GF Shen, Lei Zhang, and co‐workers.