Bipolar Affective Disorder Occurring with Psychopharmacotherapy-Induced Manic Phases

A search for publications in the PubMed/MEDLINE and RINTS databases and other sources from the mid-19th century to the present was conducted using the keywords “pharmacoinduced mania” and “bipolar affective disorder” with the aim of analyzing the stages of the formulation of the challenge, identification of the evolution of views, and the main directions of current research in the field of bipolar affective disorder (BAD) occurring with psychopharmacotherapy-induced manic phases. The issue of adequate therapy for bipolar depression became relevant in the 20th century, when numerous observations indicated that there were risks associated with the use of antidepressants in patients with BAD: the likelihood of affect inversion and exacerbation of the disorder (acceleration of cyclicity, continuous course). Expansion of research capabilities and the introduction of biological psychiatry in recent years have led to the appearance of studies addressing this problem from the perspectives of clinical, pharmacodynamic, genetic, and neurophysiological features, which opens up the prospect of developing advanced methods of personalized medicine for the diagnosis and treatment of bipolar disorders, taking into account the need to minimize iatrogenic effects.