Development and evaluation of the novel topical formulation containing Bakuchiol for enhanced skin delivery

This study investigates the encapsulation of bakuchiol, a renowned compound for hyperpigmentation treatment, utilizing transfersomes as a delivery system. The transfersomes were fabricated using the thin-film hydration technique and subjected to thorough characterization across various parameters. T...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of Research in Pharmacy 2024, Vol.28(2) (28(2)), p.470-481
Hauptverfasser: Asram SAĞIROĞLU, Ali, AYDIN, Beyza Sumeyye
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 481
container_issue 28(2)
container_start_page 470
container_title Journal of Research in Pharmacy
container_volume 28(2)
creator Asram SAĞIROĞLU, Ali
AYDIN, Beyza Sumeyye
description This study investigates the encapsulation of bakuchiol, a renowned compound for hyperpigmentation treatment, utilizing transfersomes as a delivery system. The transfersomes were fabricated using the thin-film hydration technique and subjected to thorough characterization across various parameters. The resulting transfersome formulation, after optimization, demonstrated notably high encapsulation efficiencies, with bakuchiol registering at 86.7±3.6%, accompanied by a narrow particle size distribution (179.9 ± 5.4 nm). In vitro release studies unveiled cumulative release percentages of 71.98±6.52% for bakuchiol over a 24-hour period. Ex vivo permeation studies further affirmed heightened retention of bakuchiol within the skin layers compared to control group. Stability assessments indicated that the optimized transfersome remained stable at 5°C for at least 90 days. These findings underscore the remarkable potential of transfersomes in facilitating the delivery of bakuchiol, offering a compelling and viable alternative for hyperpigmentation formulations.
doi_str_mv 10.29228/jrp.711
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_3130536353</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3130536353</sourcerecordid><originalsourceid>FETCH-LOGICAL-c250t-756c249b5cf202c02944237a0a500ab4097174586c7b0f4849ed89a5b4ccacb53</originalsourceid><addsrcrecordid>eNpN0E1LAzEQgOEgCpZa8CcEvHhZnXztbo5aP6HgRc8hm83atNtkTbKF_nuX1oOnmcPDDLwIXRO4o5LS-n4Th7uKkDM0oyWDomScn__bL9EipQ0A0FoSTsUMbZ_s3vZh2FmfsfYttnvdjzq74HHocF5b7MMkcA6DM7rHXYi7sT8BE3zWzjv_jR_1djRrF44AW7_W3tgWp63zuLW929t4uEIXne6TXfzNOfp6ef5cvhWrj9f35cOqMFRALipRGsplI0xHgRqgknPKKg1aAOiGg6xIxUVdmqqBjtdc2raWWjTcGG0awebo5nR3iOFntCmrTRijn14qRhgIVjLBJnV7UiaGlKLt1BDdTseDIqCONdVUU0012S9cZmhn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3130536353</pqid></control><display><type>article</type><title>Development and evaluation of the novel topical formulation containing Bakuchiol for enhanced skin delivery</title><source>Alma/SFX Local Collection</source><creator>Asram SAĞIROĞLU, Ali ; AYDIN, Beyza Sumeyye</creator><creatorcontrib>Asram SAĞIROĞLU, Ali ; AYDIN, Beyza Sumeyye</creatorcontrib><description>This study investigates the encapsulation of bakuchiol, a renowned compound for hyperpigmentation treatment, utilizing transfersomes as a delivery system. The transfersomes were fabricated using the thin-film hydration technique and subjected to thorough characterization across various parameters. The resulting transfersome formulation, after optimization, demonstrated notably high encapsulation efficiencies, with bakuchiol registering at 86.7±3.6%, accompanied by a narrow particle size distribution (179.9 ± 5.4 nm). In vitro release studies unveiled cumulative release percentages of 71.98±6.52% for bakuchiol over a 24-hour period. Ex vivo permeation studies further affirmed heightened retention of bakuchiol within the skin layers compared to control group. Stability assessments indicated that the optimized transfersome remained stable at 5°C for at least 90 days. These findings underscore the remarkable potential of transfersomes in facilitating the delivery of bakuchiol, offering a compelling and viable alternative for hyperpigmentation formulations.</description><identifier>ISSN: 2630-6344</identifier><identifier>EISSN: 2630-6344</identifier><identifier>DOI: 10.29228/jrp.711</identifier><language>eng</language><publisher>Istanbul: Marmara University</publisher><ispartof>Journal of Research in Pharmacy, 2024, Vol.28(2) (28(2)), p.470-481</ispartof><rights>2024. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://jrespharm.com/static.php?id=7</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>Asram SAĞIROĞLU, Ali</creatorcontrib><creatorcontrib>AYDIN, Beyza Sumeyye</creatorcontrib><title>Development and evaluation of the novel topical formulation containing Bakuchiol for enhanced skin delivery</title><title>Journal of Research in Pharmacy</title><description>This study investigates the encapsulation of bakuchiol, a renowned compound for hyperpigmentation treatment, utilizing transfersomes as a delivery system. The transfersomes were fabricated using the thin-film hydration technique and subjected to thorough characterization across various parameters. The resulting transfersome formulation, after optimization, demonstrated notably high encapsulation efficiencies, with bakuchiol registering at 86.7±3.6%, accompanied by a narrow particle size distribution (179.9 ± 5.4 nm). In vitro release studies unveiled cumulative release percentages of 71.98±6.52% for bakuchiol over a 24-hour period. Ex vivo permeation studies further affirmed heightened retention of bakuchiol within the skin layers compared to control group. Stability assessments indicated that the optimized transfersome remained stable at 5°C for at least 90 days. These findings underscore the remarkable potential of transfersomes in facilitating the delivery of bakuchiol, offering a compelling and viable alternative for hyperpigmentation formulations.</description><issn>2630-6344</issn><issn>2630-6344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpN0E1LAzEQgOEgCpZa8CcEvHhZnXztbo5aP6HgRc8hm83atNtkTbKF_nuX1oOnmcPDDLwIXRO4o5LS-n4Th7uKkDM0oyWDomScn__bL9EipQ0A0FoSTsUMbZ_s3vZh2FmfsfYttnvdjzq74HHocF5b7MMkcA6DM7rHXYi7sT8BE3zWzjv_jR_1djRrF44AW7_W3tgWp63zuLW929t4uEIXne6TXfzNOfp6ef5cvhWrj9f35cOqMFRALipRGsplI0xHgRqgknPKKg1aAOiGg6xIxUVdmqqBjtdc2raWWjTcGG0awebo5nR3iOFntCmrTRijn14qRhgIVjLBJnV7UiaGlKLt1BDdTseDIqCONdVUU0012S9cZmhn</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Asram SAĞIROĞLU, Ali</creator><creator>AYDIN, Beyza Sumeyye</creator><general>Marmara University</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>2024</creationdate><title>Development and evaluation of the novel topical formulation containing Bakuchiol for enhanced skin delivery</title><author>Asram SAĞIROĞLU, Ali ; AYDIN, Beyza Sumeyye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-756c249b5cf202c02944237a0a500ab4097174586c7b0f4849ed89a5b4ccacb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asram SAĞIROĞLU, Ali</creatorcontrib><creatorcontrib>AYDIN, Beyza Sumeyye</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of Research in Pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asram SAĞIROĞLU, Ali</au><au>AYDIN, Beyza Sumeyye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development and evaluation of the novel topical formulation containing Bakuchiol for enhanced skin delivery</atitle><jtitle>Journal of Research in Pharmacy</jtitle><date>2024</date><risdate>2024</risdate><volume>28(2)</volume><issue>28(2)</issue><spage>470</spage><epage>481</epage><pages>470-481</pages><issn>2630-6344</issn><eissn>2630-6344</eissn><abstract>This study investigates the encapsulation of bakuchiol, a renowned compound for hyperpigmentation treatment, utilizing transfersomes as a delivery system. The transfersomes were fabricated using the thin-film hydration technique and subjected to thorough characterization across various parameters. The resulting transfersome formulation, after optimization, demonstrated notably high encapsulation efficiencies, with bakuchiol registering at 86.7±3.6%, accompanied by a narrow particle size distribution (179.9 ± 5.4 nm). In vitro release studies unveiled cumulative release percentages of 71.98±6.52% for bakuchiol over a 24-hour period. Ex vivo permeation studies further affirmed heightened retention of bakuchiol within the skin layers compared to control group. Stability assessments indicated that the optimized transfersome remained stable at 5°C for at least 90 days. These findings underscore the remarkable potential of transfersomes in facilitating the delivery of bakuchiol, offering a compelling and viable alternative for hyperpigmentation formulations.</abstract><cop>Istanbul</cop><pub>Marmara University</pub><doi>10.29228/jrp.711</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2630-6344
ispartof Journal of Research in Pharmacy, 2024, Vol.28(2) (28(2)), p.470-481
issn 2630-6344
2630-6344
language eng
recordid cdi_proquest_journals_3130536353
source Alma/SFX Local Collection
title Development and evaluation of the novel topical formulation containing Bakuchiol for enhanced skin delivery
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A25%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20and%20evaluation%20of%20the%20novel%20topical%20formulation%20containing%20Bakuchiol%20for%20enhanced%20skin%20delivery&rft.jtitle=Journal%20of%20Research%20in%20Pharmacy&rft.au=Asram%20SA%C4%9EIRO%C4%9ELU,%20Ali&rft.date=2024&rft.volume=28(2)&rft.issue=28(2)&rft.spage=470&rft.epage=481&rft.pages=470-481&rft.issn=2630-6344&rft.eissn=2630-6344&rft_id=info:doi/10.29228/jrp.711&rft_dat=%3Cproquest_cross%3E3130536353%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3130536353&rft_id=info:pmid/&rfr_iscdi=true