The effect of mannitol on postoperative renal function in patients undergoing coronary artery bypass surgery: A double-blinded randomized controlled trial

Additionally, there was no statistically significant difference between two groups in terms of CPB time, aortic cross-clamp time, length of time connected to mechanical ventilation, 30-day mortality, ICU, and hospital stay time (P>0.05). Conclusion: The present study has shown that adding mannitol to the prime has no effect on kidney function, length of time connected to mechanical ventilation, length of stay in the ICU, or 30-day mortality. [...]it suggests that mannitol cannot be used as a preventative strategy for acute kidney injury after cardiac surgery. Presently, mannitol is the most commonly used additive and due to its osmodiuretic effects, it provides a higher blood oncotic pressure.4-6 This high blood oncotic pressure reduces fluid leak to third space and helps to maintain fluid balance during bypass procedure and postoperative diuresis.7 There are many studies those investigated the effects of adding mannitol to priming solution on the postoperative renal function; however the results were contradictory and it was suggested that more researches are needed to confirm its probably beneficial effects.3, 8-10 Hamiko et al reported that priming with mannitol associated with reduced incidence of postoperative delirium, decreased mechanical ventilation time, ICU and hospital stay, and lower treatment costs.11 Additionally, mannitol can induce renal vasodilation and redistribution of systemic blood flow to the kidneys." Data collection Before the operation, we recorded the patients age, sex, body surface area (BSA), history of blood pressure, diabetes, smoking, serum creatinine, and blood urea nitrogen(BUN).