Repurposing Naturally Occurring Enzymes Using Visible Light

Enzymes are natural treasure troves that hold multiple superiority. Enzymatic catalysis has become a powerful tool for asymmetric synthesis, though it is typically limited to a relatively narrow range of reaction types. By integrating the advantages of enzymatic catalysis with photocatalysis, photoenzymatic catalysis not only expands the catalytic capabilities of enzymes but also provides an effective strategy for the stereo‐control of photochemical reactions, thereby emerging as a significant research field. Herein, we focus on new‐to‐nature photoenzymatic catalysis by repurposing naturally occurring enzymes with visible light. We highlight the seminal work in reshaping various classes of enzymes, emphasizing their catalytic mechanism and synthetic potentials. Early Day Record Repurposing naturally occurring enzymes with visible light represents one of the most exciting avenues for developing new enzyme reactivity. This Emerging Topic highlights seminal work in reshaping various classes of enzymes, categorized under three mechanistic scenarios: excitation of enzymatic EDA complexes, visible‐light excitation of flavoproteins, and synergistic dual photo‐enzyme catalysis.