Thermal analysis of tetracyclines: a review

A revision on articles concerning thermal analysis of tetracyclines is presented, regarding drug-excipient compatibility, characterization of drug releasing systems, physicochemical behavior of drug-supported systems and degradation of some pharmaceuticals itself. Initially, an overview of information regarding this class of drugs is presented. A bibliographic survey revealed relatively few works on this subject despite the worldwide use and relevance of this class of antibiotics. Here, 37 papers published during the time frame 2000–2022 were classified as above and discussed once they presented thermoanalytical data straightly related to the tetracyclines. From the thermal studies of the drugs, a general decomposition behavior could be identified and it is presented.