Engineering biotin anchored-MWCNTs as a superb carrier for facile delivery of the potent Ru()-N^N scaffold in breast cancer cells

Ru( ii )-complexes have been recognised as promising in treating cancer. However, targeted delivery is an important facet to augment the efficiency of drugs. Consequently, this article portrays the construction of biotinylated-MWCNTs as an SMVT-guided nano-platform for the precise delivery of our pr...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2024-11, Vol.6 (91), p.13376-13379
Hauptverfasser:	Babu, Lavanya Thilak, Roy, Nilmadhab, Dasgupta, Tiasha, Ghosh, Sreejani, Tamizhselvi, Ramasamy, Paira, Priyankar
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biotin Biotin - chemistry Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Survival - drug effects Coordination Complexes - chemistry Coordination Complexes - pharmacology Drug Carriers - chemistry Female Humans MCF-7 Cells Nanotubes, Carbon - chemistry Ruthenium - chemistry Ruthenium - pharmacology Scaffolds
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Zusammenfassung:	Ru( ii )-complexes have been recognised as promising in treating cancer. However, targeted delivery is an important facet to augment the efficiency of drugs. Consequently, this article portrays the construction of biotinylated-MWCNTs as an SMVT-guided nano-platform for the precise delivery of our previously-developed potent Ru( ii )-scaffold, making it more effective against MCF-7 cells. This article portrays the construction of biotinylated-MWCNTs for SMVT-guided delivery of a potent Ru( ii )-scaffold into MCF7 cells.
ISSN:	1359-7345 1364-548X 1364-548X
DOI:	10.1039/d4cc04276j