Photoinduced Asymmetric Alkene Aminohetarylation with Chiral Sulfoximine Reagents
Given the pivotal role of β‐(het)arylethylamine moiety in bioactive molecules, the direct amino(het)arylation of alkenes occupies a privileged position in the construction of (het)arylethylamine derivatives. Herein we devise chiral sulfoximines as novel bifunctional reagents which exhibit remarkable...
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Veröffentlicht in: | Angewandte Chemie 2024-11, Vol.136 (47), p.n/a |
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Sprache: | eng |
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Zusammenfassung: | Given the pivotal role of β‐(het)arylethylamine moiety in bioactive molecules, the direct amino(het)arylation of alkenes occupies a privileged position in the construction of (het)arylethylamine derivatives. Herein we devise chiral sulfoximines as novel bifunctional reagents which exhibit remarkable efficiency in the challenging asymmetric alkene aminohetarylation reaction, particularly in terms of reactivity and stereo‐control. The chiral reagents can be conveniently accessed in gram scale, and efficiently generate N‐centered radicals under mild photochemical conditions. The transformation proceeds through enantioselective 1,4‐hetaryl migration, ensuring precise chirality transfer from sulfur‐ to carbon‐centers, rendering wide applicability to both aromatic and aliphatic alkenes. Furthermore, the method is straightforward to operate and does not require transition metals or photosensitizers, making it an attractive and practical option.
In this study, we devise chiral sulfoximines as novel bifunctional reagents that demonstrate high efficacy for asymmetric alkene aminohetarylation in terms of reactivity and stereo‐control. |
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ISSN: | 0044-8249 1521-3757 |
DOI: | 10.1002/ange.202408177 |