Regioselective Decarboxylative Aromatization of Benzonorcaradienes to Substituted 1‐Acylmethyl‐4‐Arylnaphthalenes

Tf2NH‐mediated decarboxylative dearomatization reaction of benzonorcaradiene γ‐ketoacids, in situ generated by intramolecular alkenylation of alkynylcyclopropane γ‐ketoacids or their tert‐butyl esters, has been described for regioselective synthesis of polyfunctionalized 1‐acylmethyl‐4‐arylnaphthale...

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Veröffentlicht in:	European journal of organic chemistry 2024-11, Vol.27 (41), p.n/a
Hauptverfasser:	Gong, Xinchi, Bu, Shixuan, Lei, Siling, Bi, Hongyan, Huang, Jianfeng, Wang, Sunewang R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynylcyclopropane Aromatization Benzonorcaradiene Decarboxylation Esters Naphthalene Regioselectivity
Online-Zugang:	Volltext
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Zusammenfassung:	Tf2NH‐mediated decarboxylative dearomatization reaction of benzonorcaradiene γ‐ketoacids, in situ generated by intramolecular alkenylation of alkynylcyclopropane γ‐ketoacids or their tert‐butyl esters, has been described for regioselective synthesis of polyfunctionalized 1‐acylmethyl‐4‐arylnaphthalenes. Tf2NH‐mediated decarboxylative dearomatization reaction of benzonorcaradiene γ‐ketoacids, in situ generated by intramolecular alkenylation of alkynylcyclopropane γ‐ketoacids or their tert‐butyl esters, has been described for regioselective synthesis of polyfunctionalized 1‐acylmethyl‐4‐arylnaphthalenes.
ISSN:	1434-193X 1099-0690
DOI:	10.1002/ejoc.202400698